Tracking brain atrophy in MS could become routine, thanks to new software

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The loss of brain tissue, called brain atrophy, is a normal part of aging, but multiple sclerosis (MS) accelerates the process. Such atrophy is a critical indicator of physical and cognitive decline in MS, yet because measuring brain atrophy is expensive and complicated, it’s done primarily in research settings. That may be changing, say scientists.

Telomere length is indicator of blood count recovery in treatment of Acute Myeloid Leukemia

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The chemotherapy treatments necessary to treat Acute Myeloid Leukemia (AML) in children can be grueling on the body, and can cause health-related complications during therapy, as well as long down the road after remission. Children receiving chemotherapy for AML receive 4 to 5 intensive chemotherapy courses, and while some children recover quickly from each course, others may take several months or more, which increases their risk for life-threatening infections.

Treating autoimmune disease without harming normal immunity

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With potentially major implications for the future treatment of autoimmunity and related conditions, scientists have found a way to remove the subset of antibody-making cells that cause an autoimmune disease, without harming the rest of the immune system. They studied an autoimmune disease called pemphigus vulgaris, a condition in which a patient’s own immune cells attack a protein called desmoglein-3 that normally adheres skin cells.

Harnessing an innate repair mechanism enhances success of retinal transplantation

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Cell replacement therapies hold promise for many age-related diseases, but efforts to bring treatments to patients have not been very successful — in large part because the newly derived cells can’t integrate efficiently into tissues affected by the ravages of aging. This is poised to change. Researchers have harnessed a naturally occurring anti-inflammatory mechanism that repaired the eye and significantly enhanced the success of retinal regenerative therapies in mice. The results could be particularly significant for macular degeneration.