Telomere length is indicator of blood count recovery in treatment of Acute Myeloid Leukemia

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The chemotherapy treatments necessary to treat Acute Myeloid Leukemia (AML) in children can be grueling on the body, and can cause health-related complications during therapy, as well as long down the road after remission. Children receiving chemotherapy for AML receive 4 to 5 intensive chemotherapy courses, and while some children recover quickly from each course, others may take several months or more, which increases their risk for life-threatening infections.

Treating autoimmune disease without harming normal immunity

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With potentially major implications for the future treatment of autoimmunity and related conditions, scientists have found a way to remove the subset of antibody-making cells that cause an autoimmune disease, without harming the rest of the immune system. They studied an autoimmune disease called pemphigus vulgaris, a condition in which a patient’s own immune cells attack a protein called desmoglein-3 that normally adheres skin cells.

Harnessing an innate repair mechanism enhances success of retinal transplantation

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Cell replacement therapies hold promise for many age-related diseases, but efforts to bring treatments to patients have not been very successful — in large part because the newly derived cells can’t integrate efficiently into tissues affected by the ravages of aging. This is poised to change. Researchers have harnessed a naturally occurring anti-inflammatory mechanism that repaired the eye and significantly enhanced the success of retinal regenerative therapies in mice. The results could be particularly significant for macular degeneration.