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Two newer epilepsy drugs may not harm the thinking skills or IQs of school-aged children whose mothers took them while pregnant — but an older drug is linked to cognitive problems in children, especially if their mothers took high doses — according to new research.
Even though the U.S. Defense Secretary Ash Carter earlier this year formally opened all combat jobs to women, based on focus groups with soldiers researchers say the U.S. military needs to work on changing significant cultural aspects to fully integrate women in the armed forces.
A team of scientists has identified powerful predictors of congestive heart failure, a major cause of hospitalization and death in the United States. A mutated gene, SLCO1B1, was found to be associated with high levels of blood fatty acid, which is a strong predictor for the development of future heart failure and the mutation itself has a direct effect on heart failure risk.
Researchers have shown that when the metabolite fumarate accumulates in a hereditary form of renal cancer it leads to an epigenetic reprogramming that drives cancer. The tumor growth mechanism seen here could be similar in other cancers, such as lung and bowel cancer, where the enzyme that breaks down fumarate is not present or not fully functional.
The microbiome of patients admitted to the intensive care unit (ICU) at a hospital differs dramatically from that of healthy patients, according to a new study. Researchers analyzing microbial taxa in ICU patients’ guts, mouth and skin reported finding dysbiosis, or a bacterial imbalance, that worsened during a patient’s stay in the hospital. Compared to healthy people, ICU patients had depleted populations of commensal, health-promoting microbes and higher counts of bacterial taxa with pathogenic strains.
Cell lines are cultured cells that are commonly used in medical research. New results show that such cells are not always what they are assumed to be. Using genetic analyses, the researchers showed that a commonly used cell line that was established almost 50 years ago does not originate from the patient it is claimed to stem from.